Publications and Presentations
2024
Visual Outcomes and Safety Data After a Single Injection of AVD-104 in Patients with Geographic Atrophy Secondary to AMD in the Phase 2a SIGLEC Trial
Glycoimmunology in the Management of Geographic Atrophy from AMD
Multifocal ERG is an Objective Endpoint for Dry AMD Studies
Autofluorescence Outcomes in Patients with Geographic Atrophy Following a Single Injection of AVD-104, a Novel Dual-Mechanism Agent that Modulates Activated Macrophages and Inhibits Complement
Results From Part 1 of the Phase 2/3 SIGLEC Trial Assessing AVD-104 for Geographic Atrophy: Glyco-immunologic Modulation of Macrophage Activity
Anatomic Changes Following a Single Injection of AVD-104 in Patients With GA Secondary to AMD in the SIGLEC Study
Geographic Atrophy: Current Treatments and Future Opportunities
Effect of AVD-104 on Visual Acuity and GA Lesions in the SIGLEC Trial
Glyco-Immune Modulation of Macrophage Activity to Treat Geographic Atrophy Associated With AMD
Novel Sialic Acid–Coated Nanoparticle AVD-104 Modulates Macrophages and Complement Dysfunction in Nonexudative AMD in Part 1 of the SIGLEC Phase 2/3 Clinical Trial
AVD-104 for Geographic Atrophy: Glyco-immunologic Modulation of Macrophage Activity
Retina Unplugged
Glyco-immune Modulation of Macrophages: Next Generation Management of Geographic Atrophy from Macular Degeneration
Corporate Overview of AVD-104
Nobody Normal Ever Accomplished Anything Meaningful
PolySialic Acid Nanoparticles Actuate Complement-Factor-H- Mediated Inhibition of the Alternative Complement Pathway: A Safer Potential Therapy for Age-Related Macular Degeneration
Sheri L. Peterson, PhD, Anitha Krishnan, PhD, Diyan Patel, MS, Amit Lad, PhD, Jutamas Shaughnessy, MD, PhD, Sanjay Ram, MD, David Callanan, MD, Derek Kunimoto, MD, Mohamed Genead, MD, Michael J. Tolentino, MD
Pharmaceuticals - MDPI
View PublicationComprehensive Ocular and Systemic Safety Evaluation of Polysialic Acid-Decorated Immune Modulating Therapeutic Nanoparticles (PolySia-NPs) to Support Entry into First-in-Human Clinical Trials
Anitha Krishnan, PhD, David Callanan, MD, Victor G. Sendra, PhD, Amit Lad, PhD, Sunny Christian, Ravinder Earla, PhD, Ali Khanehzar, PhD, Andrew J. Tolentino, BS, Valory Anne Sarmiento Vailoces, Michelle K. Greene, PhD, Christopher J. Scott, PhD, Derek Kunimoto, MD, Tarek Hassan, MD, Mohamed Genead, MD, Michael J. Tolentino, MD
Pharmaceuticals - MDPI
View PublicationInhibition of Pathologic Macrophage Activity — The Next Frontier in the Management of Geographic Atrophy Associated with AMD
Navigating the Current Anti-VEGF Treatment & Paving the Path for the Future of Retinal Vascular Disease Drug Development for Improved Patient Care
Targeting Underlying Retinal Inflammation to Avoid Disease Progression to Wet AMD
Leveraging Siglec Receptors to Repolarize Macrophages for the Treatment of Geographic Atrophy
David Callanan, MD, Tarek Hassan, MD, Derek Kunimoto, MD
Retina Today
View PublicationNovel Sialic Acid–Coated Nanoparticle, AVD-104, Modulates Macrophages and Complement Dysfunction in Nonexudative AMD in the SIGLEC Phase 2/3 Clinical Trial
AVD-104 for Geographic Atrophy: Glyco-immunologic Modulation of Macrophage Activity
Modulation of Macrophages and Complement Dysfunction in Nonexudative AMD Utilizing Novel Sialic Acid-Coated Nanoparticles
Glycomimetic Treatment of Geographic Atrophy from AMD: A Case Study
Breakthroughs in GA: Heralding the Glycomic Revolution
Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration
Michael J. Tolentino, MD, Andrew J. Tolentino, BS, Elizabeth M. Tolentino, Anitha Krishnan, PhD, Mohamed Genead, MD
Pharmaceuticals - MDPI
View PublicationPolySialic acid-nanoparticles inhibit macrophage mediated inflammation through Siglec agonism: a potential treatment for age related macular degeneration
Anitha Krishnan, PhD, Victor G. Sendra, PhD, Diyan Patel, MS, Amit Lad, PhD, Michelle K. Greene, PhD, Peter Smyth, PhD, Samantha A. Gallaher, Úna M. Herron, PhD, Christopher J. Scott, PhD, Mohamed Genead, MD, Michael J. Tolentino, MD
Frontiers in Immunology
Edited by: Bebhinn Treanor
View PublicationDeveloping Immunomodulatory Sialic Acid Mimetic Nanoparticles Therapeutics Utilizing High Affinity Ligands
Using Nature’s Design but Better… Pioneering a New Wave of Therapeutics Using Glycoimmunology
Harness the Power of Glycobiology and Nanotechnology to Address Unmet Medical Need
SIGLECs the Main Self-Pattern Recognition Receptors of the Immune System. A Promising Target for Inflammatory Modulation
Andrew J. Tolentino, BS, Michael J. Tolentino, MD, Elizabeth M. Tolentino, Anitha Krishnan, PhD, Mohamed Genead, MD
American Journal of Biomedical Science & Research
View PublicationInnovation in Treatment Modalities
Mohamed Genead, MD - Panelist
Glycoimmunology: The Next Generation Treatment Paradigm for Geographic Atrophy
Modulation of Macrophages and Complement Dysfunction in Nonexudative AMD Utilizing Novel Sialic-acid Coated Nanoparticles
View AbstractModulation of Macrophages and Complement Dysfunction in Geographic Atrophy From Macular Degeneration Utilizing Sialic-acid Coated Nanoparticles
David Chow, MD
View AbstractModulation of Macrophages and Complement Dysfunction in Nonexudative AMD Utilizing Novel Sialic-acid Coated Nanoparticles
Carl D. Regillo, MD, FACS, FASRS
View AbstractGlycoimmune Therapy as a Novel Treatment Approach for Geographic Atrophy
Sophie J. Bakri, MD, MBA, Jeffrey S. Heier, MD, Arshad M. Khanani, MD, Ma, FASRS, Baruch D. Kuppermann, MD, PhD, Carl D. Regillo, MD, FACS, FASRS, Peter K. Kaiser, MD, FASRS
View PublicationNavigating the Expanding Availability of Retinal Imaging Technologies to Transform your Clinical Pipeline
Modulation of Macrophages and Complement Dysfunction in Nonexudative Age-Related Macular Degeneration Utilizing a Sialic-acid Coated Nanoparticle.
Baruch D. Kuppermann, MD, PhD, David Callanan, MD, Tarek Hassan, MD, Michael J. Tolentino, MD, Christopher J. Scott, PhD, Mohamed Genead, MD, Anitha Krishnan, PhD
View AbstractModulation of Retinal Inflammatory Macrophages by Polysialic-Acid Coated Nanoparticles as Novel Mechanism for Nonexudative AMD Treatment.
Anitha Krishnan, PhD, , Victor G. Sendra, PhD, Amit Lad, PhD, David Callanan, MD, Tarek Hassan, MD, Michael J. Tolentino, MD, Christopher J. Scott, PhD, Mohamed Genead, MD
View AbstractTargeting Self-Recognition Pattern Receptors on Retina Immune Cells with an Engineered Glycan-coated Nanoparticle as a Novel Therapy for Nonexudative AMD.
, Amit Lad, PhD, David Callanan, MD, Tarek Hassan, MD, Michael J. Tolentino, MD, Christopher J. Scott, PhD, Mohamed Genead, MD, Anitha Krishnan, PhD
View AbstractGlycoimmunology: The Next Generation Treatment Paradigm for Geographic Atrophy
Glyco-Immunology: Attacking Dry AMD in a Different Way…
Glyco-Immunology in the Treatment of Dry AMD: Modulation of Innate Immunity with Novel Nano-Technology.
View AbstractGlyco-Immunology in the Treatment of Dry AMD: Modulation of Innate Immunity with Novel Nano-Technology.
New Wave of Glyco-Immuno Therapeutics Focus on Ophthalmology.
Investigational drugs in clinical trials for macular degeneration
Michael J. Tolentino, MD, Andrew J. Tolentino, BS
1067-1085, DOI: 10.1080/13543784.2022.2113375
View PublicationModulation of Innate Immunity & Complement Dysfunction in Patients with Geographic Atrophy Utilizing a Novel Glyco-Engineered Therapeutic Nano-Technology.
Glyco-Engineered Coated Nanoparticles A Novel Therapeutic for the treatment of Dry AMD.
Modulation of Innate Immune & Complement Dysfunction in patients with Geographic Atrophy utilizing a novel glyco-engineered therapeutic nano-technology.
Peter K. Kaiser, MD, FASRS, David Callanan, MD, Michael J. Tolentino, MD, Derek Kunimoto, MD, Mohamed Genead, MD, Anitha Krishnan, PhD
Anti-inflammatory role of a glycan-coated nanoparticle in modulating macrophages and complement in non-exudative AMD.
Anitha Krishnan, PhD; Rajesh Shinde, PhD; Derek Kunimoto, MD; Michael J. Tolentino, MD; Mohamed Genead, MD
View AbstractTargeting Innate Immune Activity in Age-Related Macular Degeneration Promising candidate molecules are in later stages of development.
Carl D. Regillo, MD, FACS, FASRS; Jeffrey S. Heier, MD
Retinal Physician, Volume: 18, Issue: April 2021, page(s): 42-45
View Publication