View Linkedin View Twitter

Publications and Presentations

2024

EURETINA | Barcelona, Spain Presentation — September 2024

Visual Outcomes and Safety Data After a Single Injection of AVD-104 in Patients with Geographic Atrophy Secondary to AMD in the Phase 2a SIGLEC Trial​​

Anat Loewenstein, MD

EURETINA Innovation Spotlight| Barcelona, Spain Presentation — September 2024

Glycoimmunology in the Management of Geographic Atrophy from AMD​​

Tarek Hassan, MD

Retina Society | Lisbon, Portugal Presentation — September 2024

Multifocal ERG is an Objective Endpoint for Dry AMD Studies​​

Raj Maturi, MD

Retina Society | Lisbon, Portugal Presentation — September 2024

Autofluorescence Outcomes in Patients with Geographic Atrophy Following a Single Injection of AVD-104, a Novel Dual-Mechanism Agent that Modulates Activated Macrophages and Inhibits Complement​​

Baruch D. Kuppermann, MD, PhD

American Society of Retina Specialists | Stockholm, Sweden Presentation — July 2024

Results From Part 1 of the Phase 2/3 SIGLEC Trial Assessing AVD-104 for Geographic Atrophy: Glyco-immunologic Modulation of Macrophage Activity​​

Rishi P. Singh, MD

American Society of Retina Specialists | Stockholm, Sweden Presentation — July 2024

Anatomic Changes Following a Single Injection of AVD-104 in Patients With GA Secondary to AMD in the SIGLEC Study​

David Boyer, MD

Clinical Trials at the Summit | Park City, Utah, United States Roundtable — June 2024

Geographic Atrophy: Current Treatments and Future Opportunities

David Callanan, MD

Clinical Trials at the Summit | Park City, Utah, United States Presentation — June 2024

Effect of AVD-104 on Visual Acuity and GA Lesions in the SIGLEC Trial

Arshad M. Khanani, MD, Ma, FASRS

Clinical Trials at the Summit | Park City, Utah, United States Presentation — June 2024

Glyco-Immune Modulation of Macrophage Activity to Treat Geographic Atrophy Associated With AMD

Tarek Hassan, MD

Club Jules Gonin | Mallorca, Spain Presentation — May 2024

Novel Sialic Acid–Coated Nanoparticle AVD-104 Modulates Macrophages and Complement Dysfunction in Nonexudative AMD in Part 1 of the SIGLEC Phase 2/3 Clinical Trial

Tarek Hassan, MD

Retina World Congress | Fort Lauderdale, Florida, United States Presentation — May 2024

AVD-104 for Geographic Atrophy: Glyco-immunologic Modulation of Macrophage Activity​

Robert Avery MD

Retina World Congress | Fort Lauderdale, Florida, United States Roundtable — May 2024

Retina Unplugged​

David Callanan, MD

BRAVS Retina Meeting 2024 | Campinas, Brazil Presenation — April 2024

Glyco-immune Modulation of Macrophages: Next Generation Management of Geographic Atrophy from Macular Degeneration

Tarek Hassan, MD

Needham Virtual Healthcare Conference | Virtual Roundtable — April 2024

Corporate Overview of AVD-104

David Callanan, MD

Vit-Buckle Society | Miami Beach, Florida, United States Award Lecture — April 2024

Nobody Normal Ever Accomplished Anything Meaningful

Tarek Hassan, MD

Original Research Publication - April 2024

PolySialic Acid Nanoparticles Actuate Complement-Factor-H- Mediated Inhibition of the Alternative Complement Pathway: A Safer Potential Therapy for Age-Related Macular Degeneration

Sheri L. Peterson, PhD, Anitha Krishnan, PhD, Diyan Patel, MS, Amit Lad, PhD, Jutamas Shaughnessy, MD, PhD, Sanjay Ram, MD, David Callanan, MD, Derek Kunimoto, MD, Mohamed Genead, MD, Michael J. Tolentino, MD

Pharmaceuticals - MDPI

View Publication
Original Research Publication - April 2024

Comprehensive Ocular and Systemic Safety Evaluation of Polysialic Acid-Decorated Immune Modulating Therapeutic Nanoparticles (PolySia-NPs) to Support Entry into First-in-Human Clinical Trials

Anitha Krishnan, PhD, David Callanan, MD, Victor G. Sendra, PhD, Amit Lad, PhD, Sunny Christian, Ravinder Earla, PhD, Ali Khanehzar, PhD, Andrew J. Tolentino, BS, Valory Anne Sarmiento Vailoces, Michelle K. Greene, PhD, Christopher J. Scott, PhD, Derek Kunimoto, MD, Tarek Hassan, MD, Mohamed Genead, MD, Michael J. Tolentino, MD

Pharmaceuticals - MDPI

View Publication
Fuji Retina | Tokyo, Japan Presentation — March 2024

Inhibition of Pathologic Macrophage Activity — The Next Frontier in the Management of Geographic Atrophy Associated with AMD

Tarek Hassan, MD

Wet AMD and Diabetic Eye Disease Drug Development Summit | Boston, Massachusetts, United States Roundtable — March 2024

Navigating the Current Anti-VEGF Treatment & Paving the Path for the Future of Retinal Vascular Disease Drug Development for Improved Patient Care

Michael J. Tolentino, MD

Wet AMD and Diabetic Eye Disease Drug Development Summit | Boston, Massachusetts, United States Presentation — March 2024

Targeting Underlying Retinal Inflammation to Avoid Disease Progression to Wet AMD

Michael J. Tolentino, MD

Publication - March 2024

Leveraging Siglec Receptors to Repolarize Macrophages for the Treatment of Geographic Atrophy

David Callanan, MD, Tarek Hassan, MD, Derek Kunimoto, MD

Retina Today

View Publication
Macula Society | Palm Springs, California, United States Presentation – February 2024

Novel Sialic Acid–Coated Nanoparticle, AVD-104, Modulates Macrophages and Complement Dysfunction in Nonexudative AMD in the SIGLEC Phase 2/3 Clinical Trial​

Peter K. Kaiser, MD, FASRS

Angiogenesis, Exudation, and Degeneration | Virtual Presentation – January 2024

AVD-104 for Geographic Atrophy: Glyco-immunologic Modulation ​of Macrophage Activity​

Carl J. Danzig, MD

Hawaiian Eye and Retina | Kauai, Hawaii, United States Presentation – January 2024

Modulation of Macrophages and Complement Dysfunction in Nonexudative AMD Utilizing Novel Sialic Acid-Coated Nanoparticles

Robert Avery MD

FLORetina | Rome, Italy Presentation – December 2023

Glycomimetic Treatment of Geographic Atrophy from AMD: A Case Study

Tarek Hassan, MD

ART Vienna | Vienna, Austria Presentation – December 2023

Breakthroughs in GA: Heralding the Glycomic Revolution

Michael J. Tolentino, MD

Original Research Publication - 16 December 2023

Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration

Michael J. Tolentino, MD, Andrew J. Tolentino, BS, Elizabeth M. Tolentino, Anitha Krishnan, PhD, Mohamed Genead, MD

Pharmaceuticals - MDPI

View Publication
Original Research Publication - 16 November 2023

PolySialic acid-nanoparticles inhibit macrophage mediated inflammation through Siglec agonism: a potential treatment for age related macular degeneration

Anitha Krishnan, PhD, Victor G. Sendra, PhD, Diyan Patel, MS, Amit Lad, PhD, Michelle K. Greene, PhD, Peter Smyth, PhD, Samantha A. Gallaher, Úna M. Herron, PhD, Christopher J. Scott, PhD, Mohamed Genead, MD, Michael J. Tolentino, MD

Frontiers in Immunology

Edited by: Bebhinn Treanor

View Publication
Drug Discovery & Lead Optimization, San Francisco, CA, United States Presentation - November 2023

Developing Immunomodulatory Sialic Acid Mimetic Nanoparticles Therapeutics Utilizing High Affinity Ligands

Michael J. Tolentino, MD

Eyecelerator, San Francisco, CA, United States Presentation - November 2023

Using Nature’s Design but Better… Pioneering a New Wave of Therapeutics Using Glycoimmunology

Mohamed Genead, MD

Glyco in Biotechnology Satellite Meeting, Big Island, HI, United States Presentation - November 2023

Harness the Power of Glycobiology and Nanotechnology to Address Unmet Medical Need

Anitha Krishnan, PhD

Original Research Publication - 27 October 2023

SIGLECs the Main Self-Pattern Recognition Receptors of the Immune System. A Promising Target for Inflammatory Modulation

Andrew J. Tolentino, BS, Michael J. Tolentino, MD, Elizabeth M. Tolentino, Anitha Krishnan, PhD, Mohamed Genead, MD

American Journal of Biomedical Science & Research

View Publication
Euretina Innovation Summit, Amsterdam, Netherlands Presentation - October 2023

Innovation in Treatment Modalities

Mohamed Genead, MD - Panelist

Ophthalmology Futures Forum, Amsterdam, Netherlands Presentation - October 2023

Glycoimmunology: The Next Generation Treatment Paradigm for Geographic Atrophy

Tarek Hassan, MD

EURETINA, Amsterdam, Netherlands Presentation - October 2023

Modulation of Macrophages and Complement Dysfunction in Nonexudative AMD Utilizing Novel Sialic-acid Coated Nanoparticles

Baruch D. Kuppermann, MD, PhD

View Abstract
Retina Society, New York, NY, United States Presentation - October 2023

Modulation of Macrophages and Complement Dysfunction in Geographic Atrophy From Macular Degeneration Utilizing Sialic-acid Coated Nanoparticles

David Chow, MD

View Abstract
ASRS, Seattle, WA, United States Presentation - July 2023

Modulation of Macrophages and Complement Dysfunction in Nonexudative AMD Utilizing Novel Sialic-acid Coated Nanoparticles

Carl D. Regillo, MD, FACS, FASRS

View Abstract
Publication - July/August 2023

Glycoimmune Therapy as a Novel Treatment Approach for Geographic Atrophy

Sophie J. Bakri, MD, MBA, Jeffrey S. Heier, MD, Arshad M. Khanani, MD, Ma, FASRS, Baruch D. Kuppermann, MD, PhD, Carl D. Regillo, MD, FACS, FASRS, Peter K. Kaiser, MD, FASRS

View Publication
Retinal Imaging Biomarkers & Endpoints Summit (2023), Boston, MA, United States Presentation - June 2023

Navigating the Expanding Availability of Retinal Imaging Technologies to Transform your Clinical Pipeline

David Callanan, MD

ARVO (2023), New Orleans, LA, United States Presentation - May 2023

Modulation of Macrophages and Complement Dysfunction in Nonexudative Age-Related Macular Degeneration Utilizing a Sialic-acid Coated Nanoparticle.

Baruch D. Kuppermann, MD, PhD, David Callanan, MD, Tarek Hassan, MD, Michael J. Tolentino, MD, Christopher J. Scott, PhD, Mohamed Genead, MD, Anitha Krishnan, PhD

View Abstract
ARVO (2023), New Orleans, LA, United States Presentation - May 2023

Modulation of Retinal Inflammatory Macrophages by Polysialic-Acid Coated Nanoparticles as Novel Mechanism for Nonexudative AMD Treatment.

Anitha Krishnan, PhD, , Victor G. Sendra, PhD, Amit Lad, PhD, David Callanan, MD, Tarek Hassan, MD, Michael J. Tolentino, MD, Christopher J. Scott, PhD, Mohamed Genead, MD

View Abstract
ARVO (2023), New Orleans, LA, United States Presentation - May 2023

Targeting Self-Recognition Pattern Receptors on Retina Immune Cells with an Engineered Glycan-coated Nanoparticle as a Novel Therapy for Nonexudative AMD.

, Amit Lad, PhD, David Callanan, MD, Tarek Hassan, MD, Michael J. Tolentino, MD, Christopher J. Scott, PhD, Mohamed Genead, MD, Anitha Krishnan, PhD

View Abstract
CTS, Salt Lake City, UT, United States Presentation - March 2023

Glycoimmunology: The Next Generation Treatment Paradigm for Geographic Atrophy

Tarek Hassan, MD

Retinal Detachment Society Meeting (2023), Snowmass, CO, United States. Presentation - March 2023

Glyco-Immunology: Attacking Dry AMD in a Different Way…

Tarek Hassan, MD

Macula Society (2023), Miami, FL, United States Presentation - February 2023

Glyco-Immunology in the Treatment of Dry AMD: Modulation of Innate Immunity with Novel Nano-Technology.

Robert Avery MD

View Abstract
8th Cairo Retina Meeting (2023), Cairo, Egypt Presentation - January 2023

Glyco-Immunology in the Treatment of Dry AMD: Modulation of Innate Immunity with Novel Nano-Technology.

Tarek Hassan, MD

3rd Dry AMD Summit (2022), Boston, MA, United States Presentation - November 2022

New Wave of Glyco-Immuno Therapeutics Focus on Ophthalmology.

David Callanan, MD

Publication - 31 October 2022

Investigational drugs in clinical trials for macular degeneration

Michael J. Tolentino, MD, Andrew J. Tolentino, BS

1067-1085, DOI: 10.1080/13543784.2022.2113375

View Publication
Retina Society (2022) Pasadena, CA, United States Presentation - October 2022

Modulation of Innate Immunity & Complement Dysfunction in Patients with Geographic Atrophy Utilizing a Novel Glyco-Engineered Therapeutic Nano-Technology.

Michael Singer, MD

OIS (2022), San Diego, CA, United States Presentation - July 2022

Glyco-Engineered Coated Nanoparticles A Novel Therapeutic for the treatment of Dry AMD.

Michael J. Tolentino, MD

CTS (2022), Incline Village, NV, United States Presentation - June 2022

Modulation of Innate Immune & Complement Dysfunction in patients with Geographic Atrophy utilizing a novel glyco-engineered therapeutic nano-technology.

Peter K. Kaiser, MD, FASRS, David Callanan, MD, Michael J. Tolentino, MD, Derek Kunimoto, MD, Mohamed Genead, MD, Anitha Krishnan, PhD

ARVO (2022), Denver, CO, United States Presentation - May 2022

Anti-inflammatory role of a glycan-coated nanoparticle in modulating macrophages and complement in non-exudative AMD.

Anitha Krishnan, PhD; Rajesh Shinde, PhD; Derek Kunimoto, MD; Michael J. Tolentino, MD; Mohamed Genead, MD

View Abstract
Publication - April 2021

Targeting Innate Immune Activity in Age-Related Macular Degeneration Promising candidate molecules are in later stages of development.

Carl D. Regillo, MD, FACS, FASRS; Jeffrey S. Heier, MD

Retinal Physician, Volume: 18, Issue: April 2021, page(s): 42-45

View Publication